Highly diastereoselective and enantioselective direct Michael addition of phthalide derivatives to nitroolefins.
نویسندگان
چکیده
The first asymmetric Michael addition of 3-substituted phthalides to nitroolefins promoted by amino acid-incorporating multifunctional catalysts has been developed. The reported method led to the synthesis of 3,3-disubstituted phthalide derivatives in high yields, and in a highly diastereoselective and enantioselective manner. Facile synthesis of a chiral bicyclic lactam has also been demonstrated.
منابع مشابه
Highly enantioselective Michael addition reactions of 2-substituted benzofuran-3(2H)-ones to nitroolefins.
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ورودعنوان ژورنال:
- Chemical communications
دوره 49 51 شماره
صفحات -
تاریخ انتشار 2013